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Obesity Medicine

A clinical and physiologic approach to obesity focused on energy balance, metabolism, nutrition, exercise, behavioral science, pharmacotherapy, obesity-related disease, and durable long-term weight management.

Obesity Medicine Topics

Explore each topic through a recent review, guideline, or evidence synthesis.

Pathophysiology of Obesity

Energy regulation, adipose biology, appetite signaling, insulin resistance, neuroendocrine control, and adaptive responses to weight loss.

Recent pathophysiology review →

Behavioral Science

Habit formation, reward learning, environmental cues, motivation, implementation intentions, and sustainable behavior change.

Recent management review →

Nutrition & Diet

Macronutrients, satiety, calorie density, dietary patterns, protein targets, meal structure, and practical nutrition strategies.

Recent comprehensive review →

Exercise Physiology

Aerobic training, resistance exercise, interval training, muscle preservation, energy expenditure, and cardiometabolic adaptation.

AHA scientific statement →

Pharmacotherapy

Anti-obesity medications, incretin-based therapy, patient selection, adverse effects, treatment response, and long-term strategy.

2025 pharmacotherapy guideline →

Obesity-Related Comorbidities

Sleep apnea, hypertension, diabetes, MASLD, dyslipidemia, osteoarthritis, and cardiometabolic risk.

Recent obesity care review →

Bariatric Procedures

Metabolic surgery, endoscopic therapies, indications, expected outcomes, and integration with longitudinal medical care.

Recent bariatric review →

Long-Term Weight Management

Weight-loss maintenance, relapse prevention, body-composition goals, follow-up, and treatment adjustment over time.

Recent weight-regain review →

Sleep & Weight Regulation

The bidirectional relationship between sleep, appetite regulation, OSA, metabolic health, and weight-loss outcomes.

Recent sleep-weight review →

Featured Obesity Teaching

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Article / Review

Why weight comes back: obesity is a biologically defended state

After weight loss, the body often responds as if it is protecting a prior weight—by increasing hunger, lowering energy expenditure, and making weight maintenance biologically harder.

Read article →